Artemisinin resistance: Cause for worry?

Benign migratory glossitis--a cause for worry?

Benign Migratory Glossitis (BMG) has been known by a variety of names including geographic tongue, erythema migrans and wandering rash of the tongue. It is not an uncommon condition and surveys showed a prevalence of below three percent in the North Americans (McCarthy 1941, Halperin 1953, and Redman 1970), and the condition may be found at any age. The male to female ratio being 1:2 (Halperin ...

Artemisinin Resistance in Falciparum Malaria

We reported two cases of complicated falciparum malaria who had poor response to artesunate with delayed parasite clearance times. They were splenectomized patients who were treated with high doses of artemisinin derivatives. Our cases showed the importance of the spleen in the clearance of malaria parasites and had different clinical outcome, one fatal and one recovery. The host factors, the p...

Artemisinin resistance in Plasmodium falciparum malaria.

BACKGROUND Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease. There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance. METHODS In two open-label, randomized trials, we compared the efficacies o...

Artemisinin Resistance in Plasmodium falciparum Malaria

Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance.

Malaria is a protozoan disease transmitted by the bite of the Anopheles mosquito. Among five species that can infect humans, Plasmodium falciparum is responsible for the most severe human malaria. Resistance of P. falciparum to chloroquine and pyrimethamine/sulfadoxine, conventionally used antimalarial drugs, is already widely distributed in many endemic areas. As a result, artemisinin-based co...